Latrophilin-1 (LPHN1), also known as adhesion G protein-coupled receptor L1 (ADGRL1), is encoded by the gene mapped to human chromosome 19p13.12. It belongs to the unique class of G protein-coupled receptors.
Synonyms: Anti-CIRL1; Anti-KIAA0821; Anti-LEC2; Anti-LPHN1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Latrophilin-1 (LPHN1) binds to black widow spider venom component a-latrotoxin (a-LTX) and promotes a surge of vesicular release from synaptic terminals and neuroendocrine cells through formation of membrane pores. LPHN1 participates in presynaptic calcium homeostasis by interaction with a teneurin ligand. In addition, it also facilitates trans-cellular adhesion through interaction with neurexins 1ß and 2ß Mutation or overexpression of LPHN1 leads to asthmatic airway smooth muscle cells (ASMC), suggesting its role in airway function.
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