GPR125 (G protein-coupled receptor 125) is a candidate marker for human spermatogonial stem cells (SSCs). It is expressed in adult mice testis and is found in long-term pre-pubertal testicular cell cultures that contain SSCs. It is an orphan GPCR. It is a homolog of TEM5 protein, and thus, is also known as TEM5-like protein. This protein is composed of 1205 amino acids, and shares homology to B family of GPCRs. This gene is localized to human chromosome 4p15.
Synonyms: Anti-FLJ38547; Anti-GPR125; Anti-PGR21
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: The function of GPR125 (G protein-coupled receptor 125) is not very clear yet. In conjunction with other stem cell markers, this protein might aid in recognizing spermatogonial subpopulations in both young and old donors. Human discs large tumor suppressor gene (hDlg) scaffolds TEM5 and GPR125 proteins in endothelial cells during angiogenesis and neoangiogensis in cancer.
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