Synonyms: Anti-alpha-Actinin-4 antibody produced in rabbit; Anti-F-actin cross-linking protein antibody produced in rabbit; Anti-Non-muscle alpha-actinin 4 antibody produced in rabbit
Storage: -20C
Application: Anti-ACTN4 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: a actinins, actin-filament crosslinking proteins, belong to the spectrin family. The two non-muscle isoforms a-actinin-1 and a-actinin-4 are expressed in podocytes. At the C terminus of ACTN4 (actinin a 4) contains a PDZ (PSD95, Dlg1 and zo-1) domain-binding motif that binds to membrane-associated guanylate kinase inverted-1 (MAGI-1) in actin cytoskeleton dynamics. It is associated with chromatin remodeling and other nuclear events. Mutation in ACTN4 gene causes nephrotic syndrome, focal and segmental glomerulosclerosis (FSGS).
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC