Actin is a highly conserved protein that is a major component of both the cytoskeletal and contractile structures in all cell types. It varies in amount, being related to the type of differentiation and to the functional state of cells and tissues. Actin can be found in two different forms of aggregation, the globular or the fibrillar state, and at least six distinct isoforms occur in vertebrates. The actins exhibit over 90% sequence homology, but each isoform has a unique NH2-terminal sequence. The isoforms are comprised of three alpha actins (skeletal, cardiac, smooth), one beta actin (beta-non-muscle) and two gamma actins (gamma smooth muscle and gamma non-muscle).
MDL Number: MFCD01092261
Storage: -20C
Application: Rabbit Anti-Actin (20-33) antibody has been used for immunoblotting assays. The product can also be used for immunohistochemistry, indirect immunofluorescence and microarray analyses.
Biochem Physiol Actions: Actin maintains the cell shape and participates in cytokinesis. Actin provides cellular strength and promotes active movement of the cell. Actin protein is essential for the formation of mature platelets. Upregulation of ACTA1 (actin, a 1) gene is observed in orthotopic liver transplantation without any earlier evidence of autoimmune liver disease.