Acyl-CoA synthetase long-chain family member 4 (Acsl4) is encoded by the gene mapped to human chromosome Xq22.3-Xq23. Acsl4 is a member of the long-chain fatty-acid-coenzyme A ligase family. All the members of this family have different substrate specificity, subcellular localization, and tissue distribution. Alternative splicing of Acsl4 gene generates two transcript variants.
Synonyms: Anti-ACS4; Anti-Acyl-CoA synthetase long-chain family member 4; Anti-FACL4; Anti-LACS4; Anti-MRX63; Anti-MRX68
Storage: -20C
Application: Anti-ACSL4 antibody produced in rabbit has been used as a mitochondria-associated membrane (MAM) marker.
Biochem Physiol Actions: Long-chain fatty-acid-coenzyme A ligase family members convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby facilitate lipid biosynthesis and fatty acid degradation. Acsl4 plays a critical role in ferroptosis execution. It also contributes to the dendritic spine architecture. Acsl4 isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the non-syndromic X-linked mental retardation or Alport syndrome.