ACADM is an acyl CoA dehydrogenase that catalyzes the first step in the ß-oxidation of mitochondrial fatty acids. ACADM mutations have been linked to medium-chain acyl-CoA dehydrogenase deficiency (MCADD) in newborns.Rabbit Anti-ACADM antibody recognizes bovine, human, mouse, and rat ACADM.
Synonyms: Anti-ACAD1; Anti-Acyl-coenzyme A dehydrogenase, C-4 to C-12 straight chain; Anti-MCAD; Anti-MCADH
Storage: -20C
Application: Rabbit Anti-ACADM antibody can be used for western blot applications at a concentration of 1 mug/ml.
Biochem Physiol Actions: ACADM Is the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Clinical phenotypes are associated with ACADM hereditary deficiency.This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.