Synonyms: GP170; MDR1; P-GP; PGY1
Storage: -20C
UNSPSC Code: 12352203
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Application: Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 45 of P Glycoprotein
Physical form: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
RIDADR: NONH for all modes of transport
WGK Germany: 1