Synonym: (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin
CAS Number: 22862-76-6
Empirical Formula (Hill Notation): C14H19NO4
Molecular Weight: 265.30
Beilstein Registry Number: 20705
EC Number: 245-269-7
MDL Number: MFCD00077650
PubChem Substance ID: 24891496
Caution
Hygroscopic
Biochem/physiol Actions
Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.
Quality Level: PREMIUM
Assay: ≥98% (HPLC)
Form: solid
Color: white to faint yellow
Solubility: H2O: soluble2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)
DMSO: soluble20 mg/mL
methanol: soluble20 mg/mL
Storage Temp.: 2-8°C