Synonyms: tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate; H2N-PEG6-CH2CH2COOtBu
Molecular Formula: C19H39NO8
Molecular Weight: 409.51
Linear Structural Formula: C19H39NO8
MDL Number: MFCD13184944
Density: 1.06581 g/mL
Refractive Index: n/D 1.4562
Storage: -20C
Application: This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC(R) molecules) for targeted protein degradation.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license