Synonyms: (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
Molecular Formula: C22H22N2O4
Molecular Weight: 378.42
Linear Structural Formula: C22H22N2O4
MDL Number: MFCD08672619
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Ambrisentan is an endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). It is 200-fold selective for the the ETA receptor subtype with a Ki of 1 nM for ETA and a Ki of 195 nM for ETB.