Synonyms: alpha-NETA; 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide; N,N,N-Trimethyl-gamma-oxo-1-naphthalenepropanaminium iodide; N,N,N-Trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium iodide; a-NETA
Molecular Formula: C16H20INO
Molecular Weight: 369.24
Linear Structural Formula: C16H20INO
MDL Number: MFCD00209857
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Originally identified as a substrate (ChA or choline)-noncompetitive, slowly reversible choline acetyltransferase inhibitor (human ChAT/BuChE/AChE IC50 = 88 nM/33.3 muM/48.6 muM; does not affect mAChRs, AChE, ChE, CrAT, ganglionic or skeletal muscular nAChRs), alpha-NETA is a fluorescent molecule (Ex 255 & 297 nm; Em 427 nm) also known for its trace amine-associated receptor 5 (TAAR5 EC50 = 150 nM) agonist and chemokine-like receptor-1 antagonist (IC50 = 375 nM; 7 nM chemerin-induced CMKLR1 beta-ARR2 recruitment) potencies both in cultures and in animal disease models in vivo (3-20 mg/kg via ip. or sc. in rats & mice).