Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Synonyms: (+/-)-alpha-Lipoic acid; (+/-)-1,2-Dithiolane-3-pentanoic acid; 6,8-Dithiooctanoic acid; DL-alpha-Lipoic acid; DL-6,8-Thioctic acid; Lip(S2)
Molecular Formula: C8H14O2S2
Molecular Weight: 206.33
Linear Structural Formula: C8H14O2S2
MDL Number: MFCD00005474
Biochem Physiol Actions: Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-kappaB. Decreases the phagocytosis of myelin by macrophages.
Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.