Tris(dimethylamino)sulfonium difluorotrimethylsilicate is widely used in organic synthesis as a source of fluoride ion for the synthesis of fluorinated compounds by C-F bond formation. It is also used as a reagent in hydrosilylation, cyanomethylation of ketones and Pd-catalyzed cross-coupling reactions.
Synonyms: TAS-F; TASF; Tris(dimethylamino)sulfur trimethylsilyl difluoride
Molecular Formula: C9H27F2N3SSi
Molecular Weight: 275.48
Linear Structural Formula: [(CH3)2N]3S[(CH3)3SiF2]
MDL Number: MFCD00012170
Storage: 2-8C
Application: Tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF2SiMe3) can be used as a mild deprotecting reagent for the cleavage of silicon protecting groups. It can also be used
•To synthesize deoxyfluoro sugars by reacting with trifluoromethanesulfonyl derivatives of partially protected sugars.
•As a reagent for the fluorination of hydroxyl-containing compounds.
Other Notes: Remainder tris(dimethylamino)sulfonium bifluoride
Beilstein Registry Number: 3577020
Empirical Formula (Hill Notation): C14H23BN2O4