Synonym(s): (Trifluoromethyl)trimethylsilane; Ruppert′s reagent; Ruppert-Prakash reagent; TFMTMS; Trifluoromethyltrimethylsilane
Formula: (CH3)3SiCF3
Formula Weight: 142.19
CAS No.: 81290-20-2
UN Number: UN1993
Density: 0.91g/mLat 20°C
Application: Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
• Palladium-catalyzed oxidative trifluoromethylation of indoles
• Preparation of 5-HT1A antagonists
• Used as difluorocarbene source
Supplemental Hazards: May form explosive peroxides.
Packaging: 10, 50 mL in glass bottle
Beilstein Registry Number: 4241868
Refractive Index: n20/D 1.386
Empirical Formula (Hill Notation): C40H56Cl3N3Pd