Synonyms: PITC
CAS Number: 103-72-0
Formula: C7H5NS
Formula Weight: 135.19
Linear Formula: C6H5NCS
MDL No.: MFCD00004798
Purity: 0.98
Boiling Point: 218 C(lit.)
Melting Point: -21 C (lit.)
Density: 1.132 g/mL at 20 C(lit.)
Refractive Index: n20/D 1.6515(lit.)
Beilstein Registry Number: 471392
EC Number: 203-138-1
UNSPSC Code: 12352100
General description: Phenyl isothiocyanate is an aromatic isothiocyanate. It participates in dehydration reactions of alcohols. It is widely used for synthesis of various biologically important heterocyclic compounds.
Application: Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.
Application: Phenyl isothiocyanate may be employed as a derivatization reagent for high-performance liquid chromatographic (HPLC) analysis of various amphetamine derivatives in body fluids for forensic purposes.Phenyl isothiocyanate (PIT) modified with polyethylene glycol (PEG), can be used as a reagent for PEGylation of protein using human serum albumin as a model protein.
RTECS: NX9275000
RIDADR: UN 2927 8(6.1) / PGII
WGK Germany: 3
Flash Point(F): 190.4 F
Flash Point(C): 88 C
R Codes: 25-34-42/43-51/53
S Codes: 23-26-36/37/39-45-61
IOD Codes: T,N
Symbol: GHS05, GHS06, GHS08
Signal Word: Danger
Hazard Statements: H301-H314-H317-H334
Precautionary statements: P261-P280-P301 + P310-P305 + P351 + P338-P310