Synonym(s): 2-Aminooxy-2-methylpropane hydrochloride; O-(1,1-Dimethylethyl)hydroxylamine hydrochloride; tert-Butoxyamine hydrochloride
Formula: (CH3)3CONH2 · HCl
Formula Weight: 125.60
CAS No.: 39684-28-1
UN Number: UN1325
Purity: ≥99.0% (AT)
Application: Reactant involved in synthesis of biologically active molecules including:
• CGS 25966 derivatives for use as MMP inhibitors
• Imidazolidinedione derivatives for use as antimalarial treatments
• Pyrimidine ribonucleotide analogs as P2Y6 receptor agonists
• Rab proteins for isoprenylation and geranylgeranylation inhibition
Reactant involved in:
• Synthesis of N-(arylethyl)-O-tert-butylhydroxamates for use as Weinreb amide equivalents
• Double allylic alkylation of indole-2-hydroxamates
• SN2 substitution reactions at amide nitrogens
• Photocycloaddition to C=N bonds for synthesis of 1,3-diazepines
Other Notes: Useful reagent for the preparation of N-tert-butoxyamino acids as substrates for the unambiguous synthesis of N-hydroxy peptides9
Packaging: 1, 5 g in glass bottle
Beilstein Registry Number: 3668106
EC No.: 254-590-1
Melting Point: ~155°C (dec.)
Empirical Formula (Hill Notation): C7H7BO4