Synonyms: HF-Pyridine; Olah's reagent; PPHF; Poly(pyridine fluoride); Pyridine hydrofluoride; Pyridinium poly(hydrogen fluoride); Pyridinium polybifluoride
CAS Number: 62778-11-4
MDL No.: MFCD00012436
Density: 1.1 g/mL at 20 C(lit.)
Storage: -20C
Beilstein Registry Number: 4750151
UNSPSC Code: 12352000
General description: May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.
Application: Convenient form of anhydrous HF, stable up to 50C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor(TM) (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.
Application: Reactant for preparation of:. Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction. Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure. Candidates for nucleic acid drugs. ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorinationReagent for:. Halofluorination reactions
RIDADR: UN 1790A2 6.1(8) / PGI
WGK Germany: 2
R Codes: 26/27/28-35-52
S Codes: 26-28-35-36/37/39-45-61
IOD Codes: T+,C
Symbol: GHS05, GHS06
Signal Word: Danger
Hazard Statements: H300 + H310 + H330-H314
Precautionary statements: Missing Phrase - N15.00950417-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338