Hexamethylphosphoramide is a polar aprotic solvent.
Synonyms: HMPA; Hexamethylphosphoric acid triamide; Tris(dimethylamino)phosphine oxide
Molecular Formula: C6H18N3OP
Molecular Weight: 179.2
Linear Structural Formula: [(CH3)2N]3PO
MDL Number: MFCD00008303
Purity: 99%
Melting Point: 7 C (lit.)
Density: 1.03 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.459 (lit.)
Application: Hexamethylphosphoramide can be used as a solvent:
•For the conversion of carboxylate salt into esters by reacting with alkyl halides.
•To synthesize aryl thioethers via nucleophilic displacement of unactivated aryl halides by thiolate ions.
•To synthesize polyazomethines (PAZs) from dialdehyde and diamine via high-temperature solution polycondensation.
Beilstein Registry Number: 1099903
EC No.: 211-653-8
Boiling Point: 230-232°C/740mmHg(lit.)
Melting Point: 7°C(lit.)
Refractive Index: n20/D 1.459(lit.)
Empirical Formula (Hill Notation): C10H12O4