Synonyms: (R)-N-Fmoc-alpha-(7-Octenyl)alanine; Fmoc-(R)-2-(7-octenyl)alanine; Fmoc-(R)-2-amino-2-methyl-dec-6-enoic acid
CAS Number: 945212-26-0
Formula: C26H31NO4
Formula Weight: 421.53
Linear Formula: C26H31NO4
MDL No.: MFCD12925761
Storage: -20C
UNSPSC Code: 12352200
Application: Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be 'stapled' via a ring closing metathesis reaction with Grubb's catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
R Codes: 50
S Codes: 61
IOD Codes: N
Symbol: GHS09
Signal Word: Warning
Hazard Statements: H400
Precautionary statements: P273