Synonyms: DIBAL; DIBAL-H
CAS Number: 1191-15-7
Formula: C8H19Al
Formula Weight: 142.22
Linear Formula: [(CH3)2CHCH2]2AlH
MDL No.: MFCD00008928
Density: 1.23 g/mL at 25 C
Storage: 2-8C
Beilstein Registry Number: 4123663
UNSPSC Code: 12352000
General description: Diisobutylaluminum hydride is a reducing agent for many functional groups commonly used in organic synthesis.
Application: Diisobutylaluminum hydride solution (1 M in dichloromethane) has been used in the conversion of esters into α-fluoro-α,β-unsaturated esters in the presence of fluorocarboalkoxy-substituted dialkyl phosphonate anions via Horner-Wadsworth-Emmons reaction. It can be used in the multi-step synthesis of (S)-2-methyl tetrahydropyridine-N-oxide, a key structural moiety of bio-active compounds like himbacine and solenopsin-A.
Application: Used in Pd-catalyzed reductive debromination of secondary alkyl bromides. O-Debenzylation and ring opening of perbenzylated furanosides. Convenient in situ generation of HZrCp2Cl from ZrCp2Cl2 and DIBAL-H.
RIDADR: UN 3394 4.3(4.2) / PGI
WGK Germany: 2
Flash Point(F): 1.4 F
Flash Point(C): -17 C
R Codes: 11-14/15-34-37-40-67
S Codes: 16-26-36/37/39-43-45
IOD Codes: F,C
Symbol: GHS02, GHS05, GHS07, GHS08
Signal Word: Danger
Hazard Statements: H225-H250-H261-H314-H335-H336-H351-H373
Precautionary statements: P210-P222-P231 + P232-P261-P280-P422
Target Organs: Blood, Central nervous system, Liver