Synonyms: POM-Cl; Pivaloyloxymethyl chloride
CAS Number: 18997-19-8
Formula: C6H11ClO2
Formula Weight: 150.6
Linear Formula: (CH3)3CCOOCH2Cl
MDL No.: MFCD00000884
Purity: 0.97
Boiling Point: 146-148 C(lit.)
Density: 1.045 g/mL at 25 C(lit.)
Refractive Index: n20/D 1.417(lit.)
Beilstein Registry Number: 1560838
EC Number: 242-735-1
UNSPSC Code: 12352100
General description: Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.
Application: Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.
RIDADR: UN 3272 3 / PGIII
WGK Germany: 3
Flash Point(F): 104 F
Flash Point(C): 40 C
R Codes: 10-20/21/22-36/37/38
S Codes: 16-26-36
IOD Codes: Xn
Symbol: GHS02, GHS07
Signal Word: Warning
Hazard Statements: H226-H302 + H312 + H332-H315-H319-H335
Precautionary statements: P261-P280-P305 + P351 + P338