Synonyms: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoic acid; AGN193109; CD 3106
Molecular Formula: C28H24O2
Molecular Weight: 392.49
Linear Structural Formula: C28H24O2
MDL Number: MFCD00943817
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: AGN 193109 is an orally active retinoic acid receptor (RAR) antagonist that targets all three RAR subtypes with higher affinity (RARalpha/beta/gamma Kd = 2 nM) than all-trans retinoic acid/ATRA (RARalpha/beta/gamma Kd = 9/12/19 nM). AGN 193109 potently antagonizes against ATRA-induced transcription in RARalpha, RARbeta, and RARgamma transfected CV-1 cells (by 85%, 62%, and 100%, respectively, by equal molar AGN 193109 against ATRA). AGN 193109 is also widely employeed to block RAR-mediated physiological and pathalogical processes in mice and rats in vivo via oral (1-10 mg/kg) or topical (0.3-36 mumol/kg) administration.