Synonyms: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; Amyloid-beta Forty-Two Inducer 4; N6-Methyl-(R)-roscovitine
Molecular Formula: C20H28N6O
Molecular Weight: 368.48
Linear Structural Formula: C20H28N6O
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Aftin-4, an amyloid forty-two inducer, activates ?-secretase, promoting the generation of amyloid-ß-1-42 (Aß1-42) from amyloid-ß protein precursor. Aftin-4 increased Aß-1-42, but not Aß-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.