Synonym: Actinomycin C1, Actinomycin IV, Dactinomycin
CAS Number: 50-76-0
Empirical Formula (Hill Notation): C62H86N12O16
Molecular Weight: 1255.42
Beilstein Registry Number: 605235
EC Number: 200-063-6
MDL number: MFCD00005033
PubChem Substance ID: 24890541
Application
Actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Actinomycin induces apoptosis and is used as a potent antitumor agent 1.
Biochem/physiol Actions
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Caution
Hygroscopic and light sensitive.
Quality Level: PREMIUM
Biological Source: from Streptomyces sp.
Assay: ~98% (HPLC)
Form: powder
Color: red, powder; red to orange
Solubility: DMSO: soluble1 mg/mL; ethanol: soluble
Storage Temp.: 2-8°C