Acetonitrile, an aliphatic nitrile, is a highly volatile, aprotic polar organic solvent that finds wide use in analytical determinations. It is UV-transparent - a property that facilitates its utilization in spectrophotometric and fluorimetric analyses. Its low viscosity, high elution strength and miscibility in water makes it viable in many chromatography systems. Its other applications include its use as a mobile phase additive and as an extraction solvent in liquid-liquid extraction (LLC), solid-phase extraction (SPE) and microextraction for chromatographic applications, etc.
Synonyms: ACN; Cyanomethane; Ethyl nitrile; Methyl cyanide
Molecular Formula: C2H3N
Molecular Weight: 41.05
Linear Structural Formula: CH3CN
MDL Number: MFCD00001878
Purity: >=99.92%
Melting Point: -45 C (lit.)
Density: 0.786 g/mL at 25 C (lit.)
Refractive Index: n20/D 1.344 (lit.)
Application: Acetonitrile, an organic solvent, is used as a mobile phase/extraction solvent in the ultra-high performance liquid chromatorgraphy - tandem mass spectrometry (UHPLC-MS) analysis of pesticides in tobacco samples. It can be potentially used with a reverse-phase column to determine the concentration of diclofenac (DCF).