Synonyms: CB 7598; 17-(Pyridin-3-yl)androsta-5,16-dien-3beta-yl acetate
Molecular Formula: C26H33NO2
Molecular Weight: 391.55
Linear Structural Formula: C26H33NO2
MDL Number: MFCD00934213
Purity: >=98% (HPLC)
Storage: -20C
Application: Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.
Biochem Physiol Actions: Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17a hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.