AAV-293 cells are an HEK293 cell line optimized for packaging of AAV virions in helper-free systems.
AAV-293 cells are derived from the commonly used HEK293 cell line but produce higher viral titers.
HEK293 cells are human embryonic kidney cells transformed by sheared adenovirus type 5 DNA.
Replication of the AAV-2 vector requires the adenovirus E1 gene product stably expressed in the HEK293-derived AAV-293 cells.
AAV-293 cells are an HEK293 cell line optimized for packaging of AAV virions in the helper-free system. AAV-293 cells, like HEK293 cells, produce E1 in trans. AAV-293 cells allow production of infectious virus particles when transfected with E1-deleted adenovirus vectors or co-transfected with the three AAV helper-free system plasmids.
These plasmids supply all of the trans-acting factors required for AAV replication and packaging in AAV-293 cells. Recombinant AAV-2 viral particles prepared from infected AAV-293 cells may then be used to infect a variety of mammalian cells.
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For research use only, not to be used in diagnostic procedures.