Synonyms: (S)-1-((S)-2-((S)-2-((10-Aminodecyl)amino)propanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide; AVP conjugate for IAP-mediated protein degrader development; SNIPER building block
Molecular Formula: C37H62N6O4
Molecular Weight: 654.93
Linear Structural Formula: C37H62N6O4
Storage: 2-8C
Application: Protein degrader building block A1V2PF1-NHEt-C10-NH2 enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC(R) degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. Building blocks in this series:917222 A1V2PF1-NHEt916943 A1V2PF1-NHEt-C6-NH2917206 A1V2PF1-NHEt-C10-NH2917451 A1V2PF1-NHEt-PEG1-NH2917702 A1V2PF1-NHEt-PEG3-NH2Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs-Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones