Synonyms: 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile; 4-Hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile; 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxothieno[2,3-b]pyridine-5-carbonitrile; A 769662; A769662
Molecular Formula: C20H12N2O3S
Molecular Weight: 360.39
Linear Structural Formula: C20H12N2O3S
MDL Number: MFCD11977269
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: A-769662 is a potent, beta1 subunit-selective, allosteric drug and metabolite (ADaM) site AMPK activator (alpha1beta1gamma1 EC50/Emax = 0.15 muM/1.99 vs. 4.51 muM/2.19 with AMP) that promotes a Thr172 phosphorylation in a beta1 carbohydrate binding module (CBM) Ser108 phosphorylation-dependent manner. A769662 synergizes with AMP as well as C2 (AMP mimetic) toward Thr172 dephosphorylated/Ser108 phosphorylated AMPK. A-769662 is widely employed in probing AMPK beta1 complexes-mediated cellular signaling in cultures (conc range: 1 muM-1 mM) as well as AMPK-dependent physiological and pathological processes in mice and rats in vivo (dosing range: 1-30 mg/kg i.p.).