7-hydroxy Methotrexate (7-hydroxy MTX) is the major metabolite of the folic acid derivative MTX (Item No. 13960).{34769} It is formed by the 7-oxidation of MTX by hepatic aldehyde oxidases. Unlike MTX, 7-hydroxy MTX does not inhibit thymidylate synthase in isolated human acute myeloid and acute lymphoblastic leukemia cells.{64002} 7-hydroxy MTX has a maximum tolerated dose of 0.1 g/kg, which is 30- to 50-fold lower than MTX, in rats.{64003} Serum levels of 7-hydroxy MTX have been used as a marker of MTX toxicity during chemotherapy.{34772,34770}
Technical Information
Formal Name
2-methyl-d3-propanedioic acid
CAS Number
42522-59-8
Synonyms
Isosuccinic Acid-d3
Methylmalonate-d3
MMA-d3
Molecular Formula
C4H3D3O4
Formula Weight
121.1
Purity
99% deuterated forms (d1-d3)
Formulation
(Request formulation change)
A solid
Solubility
(Learn about Variance in Solubility)
DMSO: slightly
Methanol: slightly
SMILES
OC(C(C([2H])([2H])[2H])C(O)=O)=O
InChi Code
InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)/i1D3
InChi Key
ZIYVHBGGAOATLY-FIBGUPNXSA-N
Shipping & Storage Information
Storage -20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
Shelf life: 4 years