Synonyms: 2'-Ddeoxy-6-thio-guanosine; 2'-Deoxy-6-thioguanosine; 2'-Deoxythioguanosine; 2-Amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-mercaptopurine; 2-Amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI); 6-Thio-dG; NSC 71261
Molecular Formula: C10H13N5O3S
Molecular Weight: 283.31
Linear Structural Formula: C10H13N5O3S
Purity: >=97% (HPLC)
Storage: -20C
Application: 6-Thio-2'-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells.
Biochem Physiol Actions: 6-Thio-2'-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo-synthesized telomeres. 6-Thio-2'-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.