Synonyms: 2,2-Bis[2-(4R,5S-diphenyl-1,3-oxazolinyl)]propane
Molecular Formula: C33H30N2O2
Molecular Weight: 486.6
Linear Structural Formula: C33H30N2O2
MDL Number: MFCD24849939
Purity: 95%
Melting Point: 164-169 C
Application: (4R,4'R,5S,5'S)-2,2'-(1-Methylethylidene) or (4S,5R)-Bis-Phbox) can be used as a ligand:
•To prepare selective exo-catalysts for enantioselective 1,3-dipolar cycloaddition reactions.
• In the asymmetric aminooxygenation of alkenes in the presence of tetramethylaminopyridyl radical (TEMPO) as an oxidant and copper(II) triflate as a catalyst.
•In asymmetric aminofluorination of olefins using an iron catalyst.This chiral Box ligand was most recently shown to mediate an asymmetric aminofluorination of olefins utlizing Xtalfuor-E (719439) and TREAT-HF (344648). The resulting cyclic carbamates can be readily converted into their concomitant beta-fluoro amino acids.
Other Notes: Iron(II)-Catalyzed Intramolecular Olefin Aminofluorination