Synonyms: beta-Monooctyl itaconate; 3-[(Octan-4-yloxy)carbonyl]but-3-enoate; 4-Octyl methylenesuccinate; n-Octyl 3-carboxy-3-butenoate
Molecular Formula: C13H22O4
Molecular Weight: 242.31
Linear Structural Formula: C13H22O4
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: The endogenous metabolite itaconate has recently emerged as a regulator of macrophage function. 4-Octyl itaconate is a cell-permeable itaconate derivative that decreases cytokine production and is protective against lipopolysaccharide-induced lethality in vivo. Esterases in mouse myoblast cells and macrophages hydrolyze it to itaconate, which alkylates cysteine residues on KEAP1, allowing the transcription factor Nrf2 to increase the expression of anti-oxidant and anti-inflammatory downstream genes.