4-Ethylphenol sodium sulfate is the sodium salt of 4-Ethylphenyl sulfate (4EPS). 4-Ethylphenyl sulfate is a gut microbial metabolite derived from tyrosine, which is converted into 4-ethylphenol and subsequently sulfated in the liver. Upregulated urine 4EPS levels are found among rats prone to insulin resistance and obesity.¹ Increased plasma 4EPS was reported in a murine model of autism, and mice treated with 4EPS displayed anxiety-like behaviours.² Higher levels of 4-ethylphenylsulfate were also found in plasma, liver, heart and kidneys in a rat model of chronic kidney disease.³ 4EPS is a component of the urine of male rats, and both 4-ethylphenyl sulfate and 4-ethylphenol are thought to participate in pheromonal communication.4,5 p-Cresol-sulfate and 4-ethylphenyl sulfate are thought to derive from tyrosine and have similar bioactivities, however their enzymatic production may differ.6
Synonyms: 4-Ethylphenyl sulfate sodium salt
Molecular Formula: C8H9NaO4S
Molecular Weight: 224.21
Linear Structural Formula: C8H9NaO4S
Purity: >=98.0% (HPLC)
Storage: -20C
Application: Metabolomics research Microbiome research