Synonyms: 3,6-Bis(methylthio)-s-tetrazine; NSC 674352; s-Tetrazine
Molecular Formula: C4H6N4S2
Molecular Weight: 174.25
Linear Structural Formula: C4H6N4S2
MDL Number: MFCD02998583
Purity: >=95% (HPLC)
Melting Point: 82-87 C
Storage: -20C
Application: 3,6-Bis(methylthio)-1,2,4,5-tetrazine can be used as a versatile building block in the inverse elecron demand hetero Diels-Alder reactions. The Boger Research Group has reported this powerful approach in the synthesis of alkaloids. It can also used to synthesize:
• Substituted indoles and indolines derivatives by sequential [4+2] cycloaddition reactions.
• 3-(Methylthio)-6-(4-morpholinyl)-1,2,4,5-tetrazine by aromatic nucleophilic substitution reaction.
Other Notes: Total Synthesis of Amaryllidaceae Alkaloids Utilizing Sequential Intramolecular Heterocyclic Azadiene Diels-Alder Reactions of an Unsymmetrical 1, 2, 4, 5-Tetrazin