3,3'-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.
Synonyms: 3,3'-Bisindolylmethane; DIM
Molecular Formula: C17H14N2
Molecular Weight: 246.31
Linear Structural Formula: C17H14N2
MDL Number: MFCD00195766
Purity: >=97.5% (HPLC)
Storage: 2-8C
Application: 3,3'-Diindolylmethane may be used as a model substrate to analyze the role of 3,3'-diindolylmethane in inducing apoptosis in human cancer cells.
Biochem Physiol Actions: Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.