Synonyms: Probe building block for photoaffinity labeling; Suzuki-Miyaura-compatible multifunctional photo probe building block; Trifluoromethyl diazirine aryl bromide
Molecular Formula: C8H4BrF3N2
Molecular Weight: 265.03
Linear Structural Formula: C8H4BrF3N2
Purity: >=95%
Storage: 2-8C
Application: 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.
Other Notes: Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction