Synonyms: 1-(Chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl methyl ether; 2-Chloro-1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one; Electrophilic scout fragment; KB03; Scout fragment for targetable cysteine
Molecular Formula: C12H14ClNO2
Molecular Weight: 239.7
Linear Structural Formula: C12H14ClNO2
MDL Number: MFCD09376367
Purity: >=95%
Storage: 2-8C
Application: 2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC(R) molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Proteomic Ligandability AssessmentThe Proteome-Wide Potential for Reversible Covalency at CysteineElectrophilic PROTACs that degrade nuclear proteins by engaging DCAF16Proteome-wide covalent ligand discovery in native biological systems