(1R,2R)-(-)-Pseudoephedrine is an enantiomer of ephedrine mainly used as a chiral auxiliary for asymmetric synthesis.
Synonyms: alpha-(1-Methylaminoethyl)benzyl alcohol; (-)-psi-Ephedrine; (-)-Pseudoephedrine; (1R,2R)-(-)-2-(Methylamino)-1-phenylpropanol; l-Pseudoephedrine
Molecular Formula: C10H15NO
Molecular Weight: 165.23
Linear Structural Formula: C6H5CH[CH(NHCH3)CH3]OH
MDL Number: MFCD00002203
Purity: 98%
Melting Point: 118-120 C (lit.)
Application: (1R,2R)-(-)-Pseudoephedrine may be used in the preparation of chiral relay ligands, which can catalyze the addition of diethylzinc to aldehydes leading to the corresponding secondary alcohol. The immobilization of pseudoephedrine on Merrifield resin forms a chiral linker, which may be used for the asymmetric alkylation of amides via solid-phase approach.