Synonym: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
CAS Number: 403811-55-2
Empirical Formula (Hill Notation): C12H11NOS2
Molecular Weight: 249.35
MDL Number: MFCD00758517
Biochem/physiol Actions
10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. It is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 mM using c-Myc transfected Rat1a fibroblasts).
Assay: ≥98% (HPLC)
Form: solid
Color: yellow
Solubility: DMSO: >10 mg/mL; H2O: <2 mg/mL
Storage Temp.: 2-8°C