Synonym: 3-Carbamyl-1-methylpyridinium chloride, MNA, N-Methylnicotinic acid amide chloride, N1-Methylnicotinamide chloride
assay ≥98% (HPLC)
form powder
color white to beige
solubility H2O: soluble15 mg/mL, clear
?storage temp. room temp
Biochem/physiol Actions
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
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