Synonyms: 2,4-Dinitrochlorobenzene; CDNB; DNCB
CAS Number: 97-00-7
Formula: C6H3ClN2O4
Formula Weight: 202.55
Linear Formula: ClC6H3(NO2)2
MDL No.: MFCD00007075
Purity: 0.97
Boiling Point: 315 C(lit.)
Melting Point: 48-50 C (lit.)
Beilstein Registry Number: 613161
EC Number: 202-551-4
UNSPSC Code: 12352100
Application: 1-Chloro-2,4-dinitrobenzene was used in determination of relative amounts of individual glutathione S-transferases subunits in human tissues by reverse-phase HPLC. It was used as contact sensitizer to study the antibacterial peptides hBD-2, -3 and -4 and LL-37 induced IL-18 protein release in human keratinocytes.
Biochem/physiol Actions: 2,4-dinitrochlorobenzene induces atopic dermatitis in BALB/c mice model.
Preparation Note: The product is dissolved in ethanol when used as glutathione S-transferase substrate and then added to a buffer to form a final concentration of 1mM in phosphate buffer (8 mL of 0.2 M KH2PO4 and 28 mL of 0.1 M Na2HPO4 per 100 mL of solution, adjusted to pH 6.5) and 4% (v/v) ethanol.
RTECS: CZ0525000
RIDADR: UN 3441 6.1 / PGII
WGK Germany: 2
Flash Point(F): 381.2 F
Flash Point(C): 194 C
R Codes: 23/24/25-33-38-41-43-50/53
S Codes: 24-28-36/37-45-60-61
IOD Codes: T,N
Symbol: GHS05, GHS06, GHS08, GHS09
Signal Word: Danger
Hazard Statements: H301 + H331-H310-H315-H317-H318-H373-H410
Precautionary statements: P261-P273-P280-P301 + P310-P302 + P350-P305 + P351 + P338