An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
Synonyms: 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem; ACPC
Molecular Formula: C4H7NO2
Molecular Weight: 101.1
Linear Structural Formula: C4H7NO2
MDL Number: MFCD00009944
Purity: >=98% (TLC)
Biochem Physiol Actions: Target IC50: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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