Synonyms: (+)-Psi; (2R,3aR,6S,7aR)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide; Phosphorus-Sulfur Incorporation Reagent
Molecular Formula: C16H16F5OPS3
Molecular Weight: 446.46
Linear Structural Formula: C16H16F5OPS3
Purity: 95%
Melting Point: 102-107 C
Application: Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (-)-PSI Reagent, is also available (cat# ALD00602). The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).
Legal Information: PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692
Other Notes: Unlocking P(V): Reagents for chiral phosphorothioate synthesisPSI on OpenFlask