Synonym: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate, Dizocilpine hydrogen maleate
CAS Number: 77086-22-7
Empirical Formula (Hill Notation): C16H15N · C4H4O4
Molecular Weight: 337.37
EC Number: 278-614-5
MDL Number: MFCD00082465
PubChem Substance ID: 24277988
Biochem/physiol Actions
Highly potent and selective non-competitive NMDA glutamate receptor antagonist that acts at the NMDA receptor-operated ion channel as an open channel blocker. Inhibits behavioral sensitization to psychostimulants and ethanol.
Form: powder
Optical Activity: [a]25/D +117°, c = 1 in methanol(lit.)
Color: white
Solubility: DMSO: >20 mg/mL; H2O: soluble6 mg/mL; 0.1 M HCl: soluble; ethanol: soluble
Gene Information: human ... GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRINA. mouse ... GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRINA. rat ... GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRINA