Synonym: 1,3,5-Estratriene-3,17ß-diol, 17ß-Estradiol, 3,17ß-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
CAS Number: 50-28-2
Empirical Formula (Hill Notation): C18H24O2
Molecular Weight: 272.38
Beilstein Registry Number: 1914275
EC Number: 200-023-8
MDL Number: MFCD00003693
PubChem Substance ID: 24278426
Packaging
1, 5, 25, 100 g in glass bottle; 250 mg in glass bottle
Biochem/physiol Actions
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
Assay: =98%
MP: 176-180 °C(lit.)
Gene Information: human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)