A mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.

An antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.

One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC₅₀ = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.

Antimycin A was initially produced by Streptomyces. Antimycin A binds cytochrome c reductase, inhibiting electron transport chain activity, oxidative phosphorylation, and ATP synthesis. Antimycin A is used in research models to study mitochondrial respiration and superoxide production. Grade: ≥98%

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…

A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC₅₀s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

A trichothecene mycotoxin that can infect grain crops causing alimentary toxic aleukia in humans and animals; inhibits protein synthesis, disrupts membrane phospholipid metabolism, increases lipid peroxides in the liver, and is highly cytotoxic to macrophages (IC50 = 19.47 nM), altering the…

A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…

Formula: C44H68O13 Formula weight: 805.02 Purity: 98% CAS Number: 78111-17-8 UN Number: UN3462 Hazard Class: 6.1 Packing Group: I Harmonized Tariff Code:  2932.19 Hazard Statements: H300-H310-H330-H315 Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled.…

CAS Number: 53003-10-4 Empirical Formula (Hill Notation): C₄₂H₇₀O₁₁ Molecular Weight: 751.00 EC Number: 258-290-1 Application Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual…

Synonym(s): Dactinomycin, Actinomycin C1 Formula: C62H86N12O16 Formula weight: 1255.40 CAS Number: 50-76-0 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H360-H351 Fatal if swallowed. May damage fertility or…

Formula: C20H37N3O13 Formula weight: 527.53 CAS Number: 31282-04-9 UN Number: UN3462 Hazard Class: 6.1 Packing Group: I Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H310-H330-H334-H318-H317 Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. May…

An active, deacetylated metabolite of T-2 toxin; inhibits protein synthesis and cell proliferation in plants; causes acute and chronic toxic effects in animals that ingest contaminated plant materials.

A fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis; exhibits minimal spectral overlap with and can be used with PE and FITC; can also be used to evaluate apoptosis and cell-mediated cytotoxicity, and to stain DNA in cells that…

A specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis and induces protein unfolding; impairs the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, IGF-IR, and ALK; radiosensitizes glioma and pancreatic adenocarcinoma cells to…

Streptolysin O (SLO) is an immunogenic, oxygen-labile toxin, hemolytic exotoxin which is reversibly activated by dithiothreitol. [1] It is released into the extracellular medium along with other toxins, including streptolysin S, during the growth of most strains of group A and many strains of…

CAS No.: 31282-04-9 UN No.: UN3462 Class: 6.1 Pkg. Group: PG II

Synonym(s): Coban r 3M, Rumensin Formula: C36H61NaO11 Formula weight: 692.86 Purity: 90-95.5% CAS Number: 22373-78-0 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300 Fatal if swallowed. Precautionary…

A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC₅₀s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

A food contaminant produced by Aspergillus that is associated with toxicity and hepatocarcinogenicity in human and animal populations.

Differs from the major microcystin variant LR with the substitution of alanine in place of the arginine; inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.

Native toxin A purified from C. difficile strain VPI10463 (toxinotype 0) MDL Number: MFCD02098001 Purity: >=95% (SDS-PAGE) Storage: 2-8C Biochem Physiol Actions: Clostridium difficile Toxin A and B, cation-dependent UDP-glucose glucosyltransferases, are cellular toxins that…

Formula: C39H64N4O16 Formula weight: 844.95 Purity: 95% CAS Number: 11089-65-9 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H330-H373 Fatal if swallowed. Fatal if inhaled. May cause damage to organs through…

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Synonyms: K-Strophanthidin-D-cymaroside;…

A mycotoxin that inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.

An intact toxin that catalyzes the ADP-ribosylation and inactivation of EF-2, terminating protein synthesis and causing cell death.

Formula: C57H82O26 Formula weight: 1183.30 Purity: 97% CAS Number: 7059-24-7 UN Number: UN3462 Hazard Class: 6.1 Packing Group: I Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H360 Fatal if swallowed. May damage fertility or the unborn child. Precautionary…

The dihydro derivative of Aflatoxin B1.

A natural oxidative metabolic product of the mycotoxin aflatoxin B2.

A selective, reversible inhibitor of V-ATPases in mammalian, plant, or fungal cells with an IC₅₀ value in the 4-400 nM range; at 100 nM, the related bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation.

A group A trichothecene mycotoxin derived by the metabolism of T-2 toxin.

A natural oxidative metabolic of the mycotoxin aflatoxin B1; produced from aflatoxin B1 in mammals and then secreted in milk.