A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,…

CAS No.: 31282-04-9 UN No.: UN3462 Class: 6.1 Pkg. Group: PG II

An active, deacetylated metabolite of T-2 toxin; inhibits protein synthesis and cell proliferation in plants; causes acute and chronic toxic effects in animals that ingest contaminated plant materials.

A mycotoxin produced by a variety of molds, including Aspergillus and Penicillium, commonly found in rotting apples; demonstrates an oral LD50 between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry and has been shown to induce nephropathy and gastrointestinal tract…

A group A trichothecene mycotoxin derived by the metabolism of T-2 toxin.

Synonym(s): Coban r 3M, Rumensin Formula: C36H61NaO11 Formula weight: 692.86 Purity: 90-95.5% CAS Number: 22373-78-0 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300 Fatal if swallowed. Precautionary…

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Synonyms: K-Strophanthidin-D-cymaroside;…

Streptolysin O (SLO) is an immunogenic, oxygen-labile toxin, hemolytic exotoxin which is reversibly activated by dithiothreitol. [1] It is released into the extracellular medium along with other toxins, including streptolysin S, during the growth of most strains of group A and many strains of…

Formula: C20H37N3O13 Formula weight: 527.53 CAS Number: 31282-04-9 UN Number: UN3462 Hazard Class: 6.1 Packing Group: I Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H310-H330-H334-H318-H317 Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. May…

A specific inhibitor of N-linked glycoslylation that blocks the first step of glycoprotein synthesis and induces protein unfolding; impairs the function of several receptor tyrosine kinases, including EGFR, ErbB2, ErbB3, IGF-IR, and ALK; radiosensitizes glioma and pancreatic adenocarcinoma cells to…

A food contaminant produced by Aspergillus that is associated with toxicity and hepatocarcinogenicity in human and animal populations.

Formula: C39H64N4O16 Formula weight: 844.95 Purity: 95% CAS Number: 11089-65-9 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H330-H373 Fatal if swallowed. Fatal if inhaled. May cause damage to organs through…

Formula: C57H82O26 Formula weight: 1183.30 Purity: 97% CAS Number: 7059-24-7 UN Number: UN3462 Hazard Class: 6.1 Packing Group: I Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H360 Fatal if swallowed. May damage fertility or the unborn child. Precautionary…

Synonym(s): (2R,3S,4S)-4-Hydroxy-2-(4-methoxybenzyl)-3-pyrrolidinyl acetate, Flagecidin Formula: C14H19NO4 Formula weight: 265.31 Purity: 97% CAS Number: 22862-76-6 UN Number: UN3462 Hazard Class: 6.1 Packing Group: III Harmonized Tariff Code:  2941.90 Hazard Statements: …

An intact toxin that catalyzes the ADP-ribosylation and inactivation of EF-2, terminating protein synthesis and causing cell death.

Synonym(s): Dactinomycin, Actinomycin C1 Formula: C62H86N12O16 Formula weight: 1255.40 CAS Number: 50-76-0 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300-H360-H351 Fatal if swallowed. May damage fertility or…

A fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis; exhibits minimal spectral overlap with and can be used with PE and FITC; can also be used to evaluate apoptosis and cell-mediated cytotoxicity, and to stain DNA in cells that…

A trichothecene mycotoxin that can infect grain crops causing alimentary toxic aleukia in humans and animals; inhibits protein synthesis, disrupts membrane phospholipid metabolism, increases lipid peroxides in the liver, and is highly cytotoxic to macrophages (IC50 = 19.47 nM), altering the…

Naturally occuring mycotoxin and food contaminant that induces the transversion of G to T at codon 249 of the p53 tumor suppressor gene and is a likely pathogen that causes hepatocellular carcinoma.

Native toxin A purified from C. difficile strain VPI10463 (toxinotype 0) MDL Number: MFCD02098001 Purity: >=95% (SDS-PAGE) Storage: 2-8C Biochem Physiol Actions: Clostridium difficile Toxin A and B, cation-dependent UDP-glucose glucosyltransferases, are cellular toxins that…

A natural oxidative metabolic product of the mycotoxin aflatoxin B2.

A cell-permeable inhibitor of HIF-1-mediated gene transcription which acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the HRE; reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50…

Formula: C28H40N2O9 Formula weight: 548.63 CAS Number: 1397-94-0 UN Number: UN3462 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2941.90 Hazard Statements: H300 Fatal if swallowed. Precautionary Statements: P264-P270-P301+P310-P321-P405-P501a Wash…

A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC₅₀s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

An antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.

A natural oxidative metabolic of the mycotoxin aflatoxin B1; produced from aflatoxin B1 in mammals and then secreted in milk.

A mycotoxin that inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.

A mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.

Antimycin A was initially produced by Streptomyces. Antimycin A binds cytochrome c reductase, inhibiting electron transport chain activity, oxidative phosphorylation, and ATP synthesis. Antimycin A is used in research models to study mitochondrial respiration and superoxide production. Grade: ≥98%

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA,…

A potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC₅₀s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.

The dihydro derivative of Aflatoxin B1.