Synonyms: tert-Butyl 4-(pyridin-2-ylcarbamoyl)piperazine-1-carboxylate; SHI-1 Molecular Formula: C15H22N4O3 Molecular Weight: 306.36 Linear Structural Formula: C15H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

Synonyms: 2-Isopropoxy-d7-phenyl N-methylcarbamate; Propoxur-d7 Molecular Formula: C11D7H8NO3 Molecular Weight: 216.28 Linear Structural Formula: C11D7H8NO3 Purity: >=98.0% (HPLC) Storage: 2-8C Legal Information: PESTANAL is a registered trademark of Sigma-Aldrich…

Synonyms: tert-Butyl 4-(4-methyl-1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate; SHI-16 Molecular Formula: C15H24N4O3 Molecular Weight: 308.38 Linear Structural Formula: C15H24N4O3 Application: Serine Hydrolase inhibitors are small molecule fragments that react in vitro with…

A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 =…

An intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates; subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.

Synonyms: (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester; 4-[[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid calcium salt;…

An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC₅₀ = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary…

Synonyms: tert-Butyl 4-((4-(trifluoromethyl)phenyl)carbamoyl)piperazine-1-carboxylate; SHI-4 Molecular Formula: C17H22F3N3O3 Molecular Weight: 373.37 Linear Structural Formula: C17H22F3N3O3 MDL Number: MFCD01763542 Application: Serine hydrolase inhibitors are small molecule…

Formula: C27H33NO4 Formula weight: 435.56 Purity: 97+% CAS Number: 57186-25-1 UN Number: UN2811 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  3002.90 Hazard Statements: H300-H310-H330-H318-H315-H335 Fatal if swallowed. Fatal in contact with skin. Fatal if…

Synonym(s): [2-(2,6-Dichloro-4-hydroxy-phenylamino)phenyl]acetic acid, 4'-OHD Formula: C14H11Cl2NO3 Formula weight: 312.15 CAS Number: 64118-84-9 UN Number: UN2811 Hazard Class: 6.1 Packing Group: III Harmonized Tariff Code:  2922.50 Hazard Statements: H301-H318-H315-H335 …

Synonyms: tert-Butyl 4-(1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate; SHI-17 Molecular Formula: C14H22N4O3 Molecular Weight: 294.35 Linear Structural Formula: C14H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

A selective inhibitor of ABHD6 (IC₅₀ = 10 nM) with negligible activity against other serine hydrolases such as DAGLβ; used both as a probe to study ABHD6 and as a negative control for studies of DAGLβ.

A cyclododecadepsipeptide potassium-selective ionophore antibotic; induces apoptosis in several cell tyes, including CHO cells, by stimulating potassium efflux.

An intermediate in the pathway leading to the production of 1,25-dihydroxy vitamin D3; plasma or serum levels are commonly used as an indicator of an individual’s vitamin D status.

A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase.

A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC₅₀ = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC₅₀s range from 1-7 μM).

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG. Molecular Formula: C18H25NO6 Molecular…

Synonyms: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione Molecular Formula: C14H7ClFN3O5 Molecular Weight: 351.67 Linear Structural Formula: C14H7ClFN3O5 MDL Number: MFCD01828668 Purity: >=98% (HPLC) Storage: -20C Biochem Physiol…

Synonyms: 2-Phenyl-3-(4-hydroxyphenyl)-5,7-bis(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine; 4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]-pyrimidin-3-yl]phenol Molecular Formula: C20H11F6N3O Molecular Weight: 423.31 Linear Structural Formula: C20H11F6N3O MDL Number: …

Synonyms: alpha,alpha-Dimethylphenethylamine hydrochloride; alpha-Benzylisopropylamine hydrochloride; 1,1-Dimethyl-2-phenylethylamine hydrochloride; 2-Methyl-1-phenylpropan-2-amine hydrochloride; 2-Phenyl-tert-butylamine hydrochloride; alpha,alpha-Dimethylphenethylamine hydrochloride Molecular…

A potent, selective antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist GSK634775 with IC₅₀ values of 2, 5, and 40 nM for rat, mouse, and human isoforms, respectively; effective in vivo, as it resolves pulmonary edema resulting from myocardial…

An analog of wortmannin; irreversibly binds PI3K; inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap cells (IC₅₀ = 1.46 μM).

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3…

A selective allosteric inhibitor of Bcr-Abl (IC₅₀s = 4.52, 0.38, and 0.93 µM against Bcr-Abl mutants G250E, E255V, and M351T, respectively); displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse…

A polymethoxylated flavone that has been shown to enhance adipogenesis and lipolysis, to inhibit α-glucosidase and α-amylase activity, and to suppress the expression of genes associated with inflammation by regulating IκBα.

A neuroexcitatory amino acid that functions as a NMDA and metabotropic glutamate receptor agonist; used to induce brain lesions in animal models of cognitive dysfunction.

Synonyms: tert-Butyl 4-(pyridin-2-ylcarbamoyl)-1,4-diazepane-1-carboxylate; SHI-2 Molecular Formula: C16H24N4O3 Molecular Weight: 320.39 Linear Structural Formula: C16H24N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

Synonyms: 1,1'-Dimethyl-4,4'-bipyridinium-2,2',3,3',5,5',6,6'-d8 dichloride; Methyl viologen-d8 dichloride; Paraquat dichloride-d8 Molecular Formula: C12D8H6Cl2N2 · xH2O Linear Structural Formula: C12D8H6Cl2N2 · xH2O MDL Number: MFCD01074178 Purity: >=98.0% (HPLC) Storage: 2-8C…

Synonyms: tert-Butyl methyl(2-(N-methyl-1H-pyrazole-1-carboxamido)ethyl)carbamate; SHI-20 Molecular Formula: C13H22N4O3 Molecular Weight: 282.34 Linear Structural Formula: C13H22N4O3 Purity: >=95% Application: Serine hydrolase inhibitors are small molecule fragments that react…

PGE1 is the theoretical COX metabolite of DGLA, but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC₅₀ of PGE1 for the inhibition of ADP-induced human platelet…

Synonyms: tert-Butyl 4-(1H-pyrazole-1-carbonyl)piperazine-1-carboxylate; SHI-14 Molecular Formula: C13H20N4O3 Molecular Weight: 280.32 Linear Structural Formula: C13H20N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…