A protein cross-linking agent isolated from G. jasminoides Ellis; inhibits UCP2 activity; 5 µM genipin increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose; induces apoptosis in FaO rat hepatoma cells and human…

=98% (HPLC), synthetic Synonym: (11a,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE CAS Number: 745-65-3 Empirical Formula (Hill Notation): C20H34O5 Molecular Weight: 354.48 Beilstein Registry Number: 5294062 EC Number: 212-017-2 MDL number: …

Synonyms: tert-Butyl 4-((2-fluorophenyl)carbamoyl)piperazine-1-carboxylate; SHI-7 Molecular Formula: C16H22FN3O3 Molecular Weight: 323.36 Linear Structural Formula: C16H22FN3O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

An intermediate produced from vitamin D2 by cytochrome P450 isoforms in vertebrates; subsequently metabolized to 1,25-dihydroxy vitamin D2, which is an agonist for the vitamin D receptor.

A colchicine derivative that inhibits tubulin polymerization (IC₅₀ = 2.1 μM) with low toxicity; suppresses microtubule dynamicity, inhibits cell migration, blocks microtubule assembly, and arrests cells in metaphase; used to synchronize cells and for karyotyping in cytogenetic studies.

Synonyms: tert-Butyl 4-(1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate; SHI-17 Molecular Formula: C14H22N4O3 Molecular Weight: 294.35 Linear Structural Formula: C14H22N4O3 Application: Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine…

An irreversible inhibitor of carnitine palmitoyltransferase 1, a mitochondrial enzyme involved in fatty acid β-oxidation (IC50 = 5-20 nM in rat liver); also acts as a direct agonist of PPARα.

An analog of wortmannin; irreversibly binds PI3K; inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap cells (IC₅₀ = 1.46 μM).

Synonyms: tert-Butyl 4-(4-methyl-1H-pyrazole-1-carbonyl)-1,4-diazepane-1-carboxylate; SHI-16 Molecular Formula: C15H24N4O3 Molecular Weight: 308.38 Linear Structural Formula: C15H24N4O3 Application: Serine Hydrolase inhibitors are small molecule fragments that react in vitro with…

A cyclododecadepsipeptide potassium-selective ionophore antibotic; induces apoptosis in several cell tyes, including CHO cells, by stimulating potassium efflux.

A polymethoxylated flavone that has been shown to enhance adipogenesis and lipolysis, to inhibit α-glucosidase and α-amylase activity, and to suppress the expression of genes associated with inflammation by regulating IκBα.

A natural type B trichothecene produced by certain species of the fungus Fusarium; inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA; passes the blood-brain barrier at different rates in different animals.

Phosmet-(dimethyl-d6) is an isotope-labeled analog of the organophosphorus insecticide, phosmet, widely used for pest control in agriculture. Synonyms: Phosmet-d6 Molecular Formula: C11D6H6NO4PS2 Molecular Weight: 323.36 Linear Structural Formula: C11D6H6NO4PS2 MDL Number: …

A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase.

A small molecule inhibitor of tankyrase 1 and 2 (IC₅₀ = 11 and 4 nM, respectively); increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin; inhibits colony formation of APC-deficient colorectal cancer cells at 0.33 µM.

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function. This modification increases the plasma half-life from 30 seconds to several hours, and permits the compound to be taken orally. Doses of 20-100 µg in humans, given 1 to 3…

Synonyms: 1,1'-Dimethyl-4,4'-bipyridinium-2,2',3,3',5,5',6,6'-d8 dichloride; Methyl viologen-d8 dichloride; Paraquat dichloride-d8 Molecular Formula: C12D8H6Cl2N2 · xH2O Linear Structural Formula: C12D8H6Cl2N2 · xH2O MDL Number: MFCD01074178 Purity: >=98.0% (HPLC) Storage: 2-8C…

Synonyms: tert-Butyl(2-(N,4-dimethyl-1H-pyrazole-1-carboxamido)ethyl)(methyl)carbamate; SHI-19 Molecular Formula: C14H24N4O3 Molecular Weight: 296.37 Linear Structural Formula: C14H24N4O3 Application: Serine Hydrolase inhibitors are small molecule fragments that react in vitro with…

Synonyms: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione Molecular Formula: C14H7ClFN3O5 Molecular Weight: 351.67 Linear Structural Formula: C14H7ClFN3O5 MDL Number: MFCD01828668 Purity: >=98% (HPLC) Storage: -20C Biochem Physiol…

An antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC₅₀ = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary…

Synonyms: 5-(4-Chloro-phenyl)-[3,3']bipyridinyl-6,6'-diamine dihydrochloride Molecular Formula: C16H13ClN4 · 2HCl Molecular Weight: 369.68 Linear Structural Formula: C16H13ClN4 · 2HCl Purity: >=98% (HPLC) Storage: room temp Biochem Physiol Actions: PF-06260933…

A noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC₅₀ = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC₅₀s range from 1-7 μM).

A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 =…

A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors.

Synonyms: 6-Amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamide; 6-Amino-N-methyl-5-(2,3,5-trichlorophenyl)-2-Pyridinecarboxamide; N-Methyl-6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxamide; PF 01247324; PF-1247324 Molecular Formula: C13H10Cl3N3O Molecular Weight: …

PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT. Synonyms: …

Synonyms: 1,3-Dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one Molecular Formula: C24H26N6O3 Molecular Weight: 446.5 Linear Structural Formula: C24H26N6O3 MDL Number: MFCD28155091 Purity: >=98%…

PGE1 is the theoretical COX metabolite of DGLA, but it is virtually undetectable in the plasma of normal humans or other animals. Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC₅₀ of PGE1 for the inhibition of ADP-induced human platelet…

Synonyms: 1'-Butyl-4'-piperidinylmethyl ester; 8-Amino-7-chloro-2,3-dihydro-1,4-benzodioxan-5-carboxylic acid; N-1-Butyl-4-piperinylmethyl)-3,4-dihydro-2H-[1,3] oxazino[3,2-a]indole-10-carboxamide; Piboserod Molecular Formula: C22H31N3O2 Molecular Weight: 369.5 Linear Structural…

Synonyms: 6''-Fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2';3',3'']terpyridine Molecular Formula: C18H19FN6 Molecular Weight: 338.38 Linear Structural Formula: C18H19FN6 Purity: >=98% (HPLC) Storage: -20C Biochem Physiol Actions: SEN177 is a…

Calcitriol is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly…

Synonym(s): N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Empirical Formula: C₂₁H₂₂N₂O₆S Linear Formula: C₂₁H₂₂N₂O₆S Formula Weight: 430.47 Purity: …